• We found few differential effects on lung function for expos

  2021-11-05

  

  We found few differential effects on lung function for exposure to mother’s and father’s smoking in relation to GSTM1 and GSTT1. However, effects related to mother’s or father’s smoking may differ because mothers tend to spend greater amounts of time with young children and mothers may also smoke du

• The GPR gene was included in

  2021-11-05

  

  The GPR35 gene was included in our survey because of its location immediately 3′ to CAPN10 and because it showed evidence of association with type 2 diabetes. Also, its expression in tissues including pancreatic islets and skeletal muscle is consistent with a possible role in type 2 diabetes. Our re

• The hypothesis that genes involved in

  2021-11-05

  

  The hypothesis that genes involved in type 2 diabetes evolved under changing selective pressures and may carry the signature of natural selection motivated us to describe patterns of sequence variation at CAPN10 and GPR35 in human populations. An initial population genetics study reported an unusual

• The HH Gli pathway has been demonstrated

  2021-11-05

  

  The HH-Gli pathway has been demonstrated to play an extensive role in skeletal development. India Hedgehog, derived from hypertrophic chondrocytes, and Parathyroid Hormone-like related Protein (PTHrP), derived from peri-articular chondrocytes, form a negative feedback loop to inhibit chondrocyte hyp

• Introduction Since the development of

  2021-11-05

  

  Introduction Since the development of the first radioimmunoassay (RIA) to measure hormone levels in the late 1950s, for which Rosalyn Sussman Yalow was awarded the Nobel Prize for Medicine in 1977 (the second woman ever receiving it), the use of TNP-470 in molecular research has increased tremendo

• Moving forward to series the energy

  2021-11-05

  

  Moving forward to series , the energy minimized conformation of proton pump inhibitor within the binding pocket is quite interesting. The indole-based tail guides the TZD head for a highly-favored interaction with all residues of the H-bonding triad (). In addition, an extra bonding with H449 in t

• In regards to animals several studies have reported the

  2021-11-05

  

  In regards to animals, several studies have reported the peroxisomal localization of FPS (Krisans et al., 1994, Olivier et al., 2000, Kovacs et al., 2007). Transfections of mammalian cells with the rat short FPS isoform followed by immunodetection localized the enzyme to the peroxisome (Olivier et a

• Management of HIV treatment with HIV

  2021-11-05

  

  Management of HIV-1 treatment with HIV PIs can be complicated due to wide inter-patient variability in BCA Protein Quantitation Kit australia levels. In certain scenarios, therapeutic drug monitoring (TDM) has been recommended as a useful approach to individualize therapy for HIV-infected patients

• Recent studies in our laboratory demonstrated

  2021-11-05

  

  Recent studies in our laboratory demonstrated that several histamine H1 receptor antagonists induce apo A-I gene expression while histamine itself represses it [20]. In humans, there are three histamine receptor genes (H1, H2, and H3) that code for G-protein-coupled receptors (GPCR's) which bind his

• According to the literature HER mutations

  2021-11-05

  

  According to the literature, HER2 mutations are present in 2–4% of lung adenocarcinoma (ADC) patients. Most HER2 mutations are in-frame insertional mutations occurring at exon 20 in the protein kinase domain [[2], [3], [4], [5]]. Although several small molecules and HER2 DDD107498 have been tested

• br Discussion The aminoglycoside antibiotic

  2021-11-04

  

  Discussion The aminoglycoside antibiotic gentamicin continues to be an important agent against life threatening infections. However, nephrotoxicity is a major complication of the gentamicin administration. Thus amelioration of nephrotoxicity would enhance its clinical use. Several approaches invo

• We also demonstrated that inhibition of NAAG hydrolysis

  2021-11-04

  

  We also demonstrated that inhibition of NAAG hydrolysis to suppress glutamate production through a GCPII inhibitor is a viable target for cancer therapy. GCPII is also known as N-acetyl-L-aspartyl-L-glutamate peptidase I (NAALADase I) or NAAG peptidase (Pinto et al., 1996), and its increased express

• br Materials and methods br Results br Discussion To the

  2021-11-04

  

  Materials and methods Results Discussion To the best of our knowledge, the current study presented the first evidence that GPR40, also named FFAR1, played an essential role in bone formation and mediated Sennoside D receptor induced osteogenic effect via Wnt/β-catenin signaling. We found t

• br Methods br Results and discussion Protein analysis

  2021-11-04

  

  Methods Results and discussion Protein analysis of commonly used cell lines (C6, D54-MG, U87, U251 and STTG1) reveals high how to calculate molar concentration of SXC (Cho and Bannai, 1990, Ye et al., 1999, de Groot et al., 2005, Lyons et al., 2007, Savaskan et al., 2008). Since protein expre

• br Acknowledgements br Introduction Protein translation dema

  2021-11-04

  

  Acknowledgements Introduction Protein translation demands high fidelity. There are number of molecular checkpoints to fulfill this demand. Among these, insuring that a particular tRNA gets aminoacylated by its conjugate amino acid, which in turn is catalyzed by a particular aminoacyl-tRNA synt

15488 records 537/1033 page Previous Next First page 上5页 536537538539540 下5页 Last page