• At the mechanistic level our results strongly suggested

  2019-04-24

  

  At the mechanistic level, our results strongly suggested that the cholestatic protective effect of STS was most likely accounted for by the activation of LXR, a nuclear receptor known for its anti-cholestatic activity. The activation of LXR was supported by the induction of typical LXR target genes,

• The study by Wan Ling Wong and

  2019-04-24

  

  The study by Wan Ling Wong and colleagues examines the overall prevalence of age-related macular degeneration. In agreement with previous studies, Wong and colleagues have projected that 196 million people will be affected by age-related macular degeneration in 2020, increasing to 288 million by 204

• El resultado de esta reuni n

  2019-04-24

  

  El resultado de esta reunión se plasmó en una serie de resoluciones que transcribe Elena Aub en su libro sobre el me/59. En resumen, se acordaba un programa de máximos para España en el que se señalaba el restablecimiento de todas las libertades políticas, el derecho de autodeterminación de Cataluña

• Si se orienta seg n el

  2019-04-24

  

  Si se orienta según el procedimiento de la fórmula de transición adoptada, el mejor tipo de justicia transicional para Colombia sería el de las transiciones democráticamente legitimadas, el cual consiste en: Un modelo óptimo sería entonces el que combine tanto los perdones “responsabilizantes” y el

• her2 inhibitor Adenosine is a kind of widely distributed

  2019-04-23

  

  Adenosine is a kind of widely distributed endogenous nucleoside. Adenosine receptor includes three types: A1, A2 and A3. Cumulative animal studies have proved the neuroprotective effect of adenosine in ischemia-reperfusion injury. For example, blockade of A1 adenosine receptor by DPCPX, a selective

• br Tuberculosis remains a global emergency and continues

  2019-04-23

  

  Tuberculosis remains a global emergency and continues to present major public health challenges worldwide. The actual global burden of tuberculosis can only be estimated because no accurate data are available from national country programmes from of high tuberculosis endemic countries. The WHO 201

• En ambos conjuntos hay animales

  2019-04-23

  

  3. En ambos conjuntos hay animales comunes debido a su apariencia física, aunque sus conductas y propiedades difieren en forma notable. Es el caso del pelícano, mono, cocodrilo, camaleón, venado, bisonte, lobo, perro, sirena, etc. Otros más tienden a ser confundidos mediante una asimilación comparat

• Introduction Acute myeloid leukemia AML is a rare

  2019-04-23

  

  Introduction Acute myeloid leukemia (AML) is a rare disease afflicting annually 3–4 persons per 100,000 individuals. With a median age at diagnosis of 67 years, this disease is far more common in the elderly [1]. In this age group, AML has a particularly dismal outcome with less than 5% of the pati

• The starting point is to address the huge gap

  2019-04-23

  

  The starting point is to address the huge gap in surveillance capabilities identified in 2014 by the WHO\'s first global report on surveillance of antimicrobial resistance. To address this SRT 1720 gap, WHO\'s action plan is being implemented in phases from early 2016 onwards, gathering information

• Previous studies have demonstrated localization of miR stain

  2019-04-23

  

  Previous studies have demonstrated localization of miR-21 staining in stromal SB525334 of OSCC associated with the tongue and mouth floor—this might be a useful prognostic predictor. We also observed miR-21 staining in the stromal cells of tumors. However, since multiple lines of evidence indicate

• br Discussion Our case demonstrates feasibility for

  2019-04-22

  

  Discussion Our case demonstrates feasibility for improvement in erythropoiesis in a patient with poor predictor of ESA/G-CSF response/growth factor refractory, low-risk MDS who was treated with sertraline for co-morbid depression. Within 100 days concurrent administration of sertraline, ESA and G

• Introduction Hepatosplenic T cell lymphoma HSTCL is a rare

  2019-04-22

  

  Introduction Hepatosplenic T-cell lymphoma (HSTCL) is a rare subtype of peripheral T-cell lymphoma, which is derived from cytotoxic T-cells typically expressing γδ T-cell receptor (TCR). It usually occurs in young men and is characterized by B symptoms such as a fever, weight loss and night sweats,

• br In a Comment February

  2019-04-22

  

  In a Comment (February, 2017), we argued that action on the conditions currently referred to as non-communicable diseases (NCDs) may be hampered by the inadequacy of their label. We received a remarkable amount of feedback on this suggestion, and in this Comment we synthesise the responses garnere

• order substance p Bacterial LPS stimulates monocytes and tis

  2019-04-22

  

  Bacterial LPS stimulates monocytes and tissue macrophages to release TNF-α and IL-1, which then stimulate secondary response cytokines, including IL-6. In addition to hematopoietic cells, IL-6 is synthesized by many different types of nonhematopoietic cells, including endothelium, lasting for an ext

• Introduction Personalized medicine is the major goal

  2019-04-22

  

  Introduction Personalized medicine is the major goal of translational research in the post-genomic era. Numerous biomarkers have been identified by genomic or proteomic approach that can reclassify the disease pak1 and predict clinical outcome. However, to define a specific disease phenotype, it i

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