• br Acknowledgements br Introduction The chronic myeloprolife

  2019-06-01

  

  Acknowledgements Introduction The chronic myeloproliferative neoplasms (MPN) comprise a group of clonal stem cell disorders with a high prevalence of the JAK2 V617F mutation (JAK2+) causing excessive production of mature blood cells. Transformation to acute myeloid leukemia (AML) is seen in 2–

• Conflict of interest br Authors contributions br Acknowledgm

  2019-06-01

  

  Conflict of interest Authors׳ contributions Acknowledgments This work was supported by grants from the Associazione Italiana Lotta alle Leucemie, Linfoma e Mieloma (AIL) – Sezione ‘Luciano Pavarotti’ Modena-ONLUS (to FF and LP) and from the Associazione Italiana per la Ricerca sul Cancro (AIR

• br Conflict of Interest br Acknowledgments br

  2019-06-01

  

  Conflict of Interest Acknowledgments Introduction Human ether-a-go-go-related gene (hERG) encodes the alpha subunit of the rapidly-activating delayed-rectifier K+ channel, which plays a pivotal role in repolarization of cardiac action potentials (APs) [1]. Most of mutant hERG proteins causi

• br In a Comment February we argued that action on

  2019-06-01

  

  In a Comment (February, 2017), we argued that action on the conditions currently referred to as non-communicable diseases (NCDs) may be hampered by the inadequacy of their label. We received a remarkable amount of feedback on this suggestion, and in this Comment we synthesise the responses garnere

• Lead failures are classified as

  2019-05-31

  

  Lead failures are classified as either structural lead failures or electrical lead failures, and failures of 8F single coil leads are more frequently reported. Structural failures occur with a reported incidence of 14–34% and are evident as cable exteriorization in fluoroscopy studies [6,7]. Electri

• br Materials and methods br Results br Discussion Osteosarco

  2019-05-31

  

  Materials and methods Results Discussion Osteosarcoma derives from primitive bone-forming mesenchymal cells and is the most common type of primary bone malignancy [20]. Over the past few decades, the introduction of combinatorial chemotherapy has improved the 5-year overall survival rate of

• Como es l gico hay un

  2019-05-31

  

  Como es lógico, hay un personaje que hace de contrapunto challenge esa posición y que por ello mismo la vuelve, por efecto de una diférance (Derrida 1972b), mucho más significativa. Lily, la mujer de Nicolás, no comprende ni lo más mínimo la fascinación que ejerce sobre su marido esa novela. La razó

• br This year marks years

  2019-05-31

  

  This year marks 20 years since 189 countries signed the Beijing Declaration and Platform for Action and committed to prioritisation of women\'s empowerment and gender equality. Yet a recently released UN analysis shows that violence against women persists at “alarmingly high levels”. Worldwide, on

• Atrial fibrosis is one of the

  2019-05-31

  

  Atrial fibrosis is one of the fundamental mechanisms for the pathogenesis of atrial fibrillation (AF), but the underlying electrophysiological changes involved are not completely understood. Aging, neurohumoral activation, and chronic atrial stretch due to structural heart disease activate various s

• br II En lo que sigue proponemos

  2019-05-31

  

  II En lo que sigue, proponemos un análisis de El fistol del diablo que parte inicialmente de una etnografía simbólica de objetos de valor estético —caso ilustrado en la novela de Payno con un fistol de diamante engastado—, con raíces en leyendas y en la historia literaria de varias naciones del m

• De hecho la Am rica po

  2019-05-31

  

  De hecho la América poética comparte con estos periódicos especializados un mismo receptor, una misma nómina de suscriptores que gustan de la poesía lírica, un mismo “público ilustrado e igualmente sensible order LY294002 la razón del filósofo y al arte del poeta romántico” (Batticuore: 113). Estas

• Predicting the potential effects of climate

  2019-05-30

  

  Predicting the potential effects of climate change on the incidence and distribution of infectious gastroenteritis can assist public health providers to control and prevent severe outbreaks in the future. Implementation of programmes for rotavirus vaccination clearly shows benefit and should be an d

• br Rheumatic heart disease RHD affects over

  2019-05-30

  

  Rheumatic heart disease (RHD) affects over 32 million people worldwide; the vast majority of patients are in low-income and middle-income countries. It is a leading cause of premature mortality in children and young adults living in endemic regions. Patients with RHD often present in an advanced s

• Amiodarone has been used in Japan for more

  2019-05-30

  

  Amiodarone has been used in Japan for more than 5 years now since its approval in July 2007, and intravenous amiodarone has been widely used for life-threatening ventricular tachycardia in the setting of critical care medicine. However, only few reports have been published in the international liter

• In addition to inducing IKs

  2019-05-30

  

  In addition to inducing IKs dysfunction through dominant-negative loss-of-function effects and defective channel trafficking, mutations in KCNQ1 suppress IKs channel function by reducing the channel affinity of interacting proteins [68,69]. Phosphatidylinositol-4,5-bisphosphate (PIP2) is a cofactor

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