• Pilsicainide might increase hERG proteins

  2019-06-05

  

  Pilsicainide might increase hERG proteins via facilitating the transcription of hERG from DNA to RNA or the translation of hERG RNA into hERG protein. Qualitative RT-PCR demonstrated the absence of an increase in hERG mRNA expression levels after pilsicainide treatment (Supplemental Fig. S2), indica

• br Tara Mangal and colleagues document the struggle

  2019-06-05

  

  Tara Mangal and colleagues document the struggle to eliminate polio in northern Nigeria. However, they overlook the importance of routine immunisation to polio eradication efforts. The investigators identified an association between the risk of contracting polio and oral polio vaccine unavailabil

• Los tres especialistas invitan a volver

  2019-06-05

  

  Los tres especialistas invitan a volver la mirada hacia la figura polémica de Las Casas y su Brevíssima relación desde nuestro complejo presente, para interpelarnos como lectores críticos del siglo xxi acerca de la dolorosa historia gsk-3 de América Latina. Cronista que “ve la realidad tal cual

• I received a grant from The Kendeda

  2019-06-05

  

  I received a grant from The Kendeda Fund to write and promote my book, , on which this comment is based. I thank Richard King (Chatham House, London, UK) for data assistance, Christian Guthier (All is Possible, Oxford, UK) for graphic design, and Sarah Cornell (Stockholm Resilience Centre, Stockholm

• This report illustrates an unusual case of CMML which transf

  2019-06-05

  

  This report illustrates an unusual case of CMML which transformed to AML rapidly with emergence of the rare e6a2 fusion transcript. The possibility CML in blasts crisis was excluded as the CMML biopsy showed dysgranulopoiesis and lacked Ph chromosome and BCR-ABL1 fusion transcript. We further revi

• Perhaps counter intuitively the most

  2019-06-05

  

  Perhaps counter-intuitively, the most strategic tobacco control policies to reduce adolescent smoking and secondhand smoke exposure in LMICs may not be those targeting adolescents. Targeted campaigns can be expensive, and are unlikely to be as effective as the more affordable tobacco control policie

• In addition the TAA treated groups show http www

  2019-06-05

  

  In addition, the TAA-treated groups showed a significant reduction in body weight with significantly increased liver weights and sizes compared to control rats, but NJ cotreatment reversed those defects (Table 1). The reduction in body weights could be attributed to the toxic effect of TAA throughou

• br Discussion Catheter ablation has played an increasingly

  2019-06-05

  

  Discussion Catheter ablation has played an increasingly important role in controlling VT episodes in patients with structural glucocorticoid receptors disease who have an ICD [6–10]. LPs recorded at an endocardial ventricular site reflect slow conduction into a protected zone. Strategies for the

• In focal coronary spastic angina intravascular

  2019-06-05

  

  In focal coronary spastic angina, intravascular ultrasound was reported to detect intima–media complex thickening and an increased sonolucent zone [16,17], and OCT can detect intimal thickening with low lipid and calcium deposits [18], which are believed to reflect neointimal hyperplasia subsequent

• Calkins et al demonstrated that

  2019-06-05

  

  Calkins et al. demonstrated that volume loading has a greater electrophysiological significance under pathologic conditions such as chronic infarction [8]. Some vasodilators can counteract such electrophysiological changes and suppresses VT. Captopril prolonged the ventricular refractory endothelin

• En el libro de Morales Carazo este transparente desciframien

  2019-06-01

  

  En el libro de Morales Carazo este transparente desciframiento del nacionalismo oculto de los “contras”, se produce con urotensin ii en un acto de enmascaramiento literario, que refiere a Pablo Antonio Cuadra. El autor hace una lectura del sujeto campesino y sus valores a partir de su convivencia c

• Qu dicen las fechas en que se

  2019-06-01

  

  ¿Qué dicen las fechas en que se ha flexibilizado la posición de ambas partes? Veamos una cita elocuente sobre la situación internacional en la década de los años setenta del siglo pasado, marco en el que se mejoraron las relaciones entre Washington y La Habana, bajo el gobierno de James Carter. Por

• br Purpose br Methods Participating centers Forty main ICSD

  2019-06-01

  

  Purpose Methods Participating centers: Forty main ICSD centers in Japan from Hokkaido to Okinawa, which cover approximately 20% of all new ICSD patients in Japan, are participating in the present study. After obtaining written informed consent, all patients (over 20 years old) will be register

• Current ASCO recommendations suggest initiating

  2019-06-01

  

  Current ASCO recommendations suggest initiating bisphosphonate therapy in myeloma when there is evidence of bone involvement [124]. The optimal duration and frequency of bisphosphonate therapy for myeloma are not well understood and are currently being studied. All randomized, placebo-controlled tri

• In patients who develop bone metastases these are commonly d

  2019-06-01

  

  In patients who develop bone metastases, these are commonly diagnosed at the time of their initial work up for their metastatic disease (∼80%) [7], although others can develop skeletal metastases at any time during the disease course. The consequences of bone metastases include pain (∼80%) [3,6,8] a

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